x biotech ecole des mines 24 april 2006 1 agenda pharmaceutical industry context antibiotic therapeutic area creation and structure of novexel sa pipeline attributes milestones 2 bigger is better 1992 sales 226 billion market share merck & co 3 9 glaxo 7 bms ciba geigy 8 skb hoechst 5 j&j ahp 4 pfizer bayer top 10 28 2004 550 gsk 6 0 sanofi aventis novartis az roche wyeth 45 source ims growth through m&a kabi pharmacia 1993 farmitalia carloerba 1995 upjohn 1999 sugen 2000 searle monsanto 2001 2003 ranking 41 role usa 34 35 17 14 47 30 11 12 north america europe japan other 2005 566 218 the r&d process one third molecules now in development originated companies economist survey june basic research discovery pre clinical
