an overview of research on location and economic activity with specific reference to r&d the pharmaceutical industry jeffrey l furman boston u & nber january 21 2005 questions general which factors affect innovative firm level decisions about where locate facilities in biotechnology industries does pharma bio performance productivity drug discovery motivating quote when has thus chosen a locality for itself it is likely stay there long so great are advantages people following same skilled trade get from near neighbour hood one another mysteries become no but as were air children learn many them unconsciously alfred marshall principles economics 1890 early recent classical von thünen 1826 weber 1909 farming locations minimize transportation costs co agglomeration encouraged by