pakistan j med res vol 43 no 4 2004 safety of medicinal plants inamul haq ex drug controller ministry health government islamabad summary the last decade has witnessed a great revival interest in use herbal medicines both developed as well developing countries almost 50 we today are derived straight from and 25 prescription drugs have their genesis tropical according to who 80 world population rely chiefly on plant based traditional specially for primary care needs common belief tradition that being natural or near nature always safe is not held be true lately advancement technology enabled scientists detect minute amounts carcinogenic toxic chemicals these herbs recognize evaluate potentially hazardous effects some used since centuries this article aims highlight side adverse reactions interactions few most commonly considered with an advise physicians pharmacists consider hazards associated