World Chiral Technology Market

CHIRAL TECHNOLOGY MCP-1098
A GLOBAL STRATEGIC BUSINESS REPORT

CONTENTS

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3
Chiral Technology Enabling Products I-4
Chiral Intermediates I-4
Analytical Products I-4
Other Products I-4
Chiral Technology End-Use Products I-4
Pharmaceuticals I-4
Agrochemicals I-4

II. EXECUTIVE SUMMARY

1. Introduction II-1
An Insight into Chiral Technology II-1
Techniques Used for Achieving Single-Isomers II-1
Table 1: World Chiral Technology Market (2002 & 2010):
Percentage Breakdown of Revenues by Techniques- Traditional
Methods, Asymmetric Methods, and Biological Methods (includes
corresponding Graph/Chart) II-2
Importance and Advancements II-2

2. Global Market Overview II-4
Outlook and Trends II-4
Good Tidings for Chiral Technology II-4
Market Drivers II-5
Demand for Chiral-based Therapeutic Drugs Augments Growth II-5
New Legislations Push Chiral Technology Demand II-5
Key Trends II-6
Organizations Extend Approaches II-6
Companies� Association with Universities II-6

3. Chiral Technology - An Overview II-7
Definitions II-7
Chiral Technology Enabling Products II-7
Chiral Intermediates II-7
Analytical Products II-7
Other Products II-7
Chiral Technology End-Use Markets II-7
Pharmaceuticals II-7
Agrochemicals II-8
Description II-8
Functioning of Chiral Molecules II-9
Chiral Preparation Process II-9
Traditional Methods II-9
Biological Methods II-9
Asymmetric Methods II-10
Chiral Separation II-10
Chromatography - The Widely Used Method for Separation II-10
How it Works? II-11
Chiral Mobile Phase Additive (CMPA) II-11
Chiral Stationary Phase (CSP) II-11
Chiral Recognition II-12
Protein Chiral Stationary Phases II-12
Carbohydrate Columns II-12
Pirkle Columns II-12
Crystallization II-12
Solvent Extraction II-13
Kinetic Resolution II-13
Capillary Electrophoresis II-14
Receptor Based Resolution II-14
Miscellaneous Separative Techniques II-14
Chiral Synthesis II-14

4. Chiral Technology - Development vs. Acquisition II-16
In-House Creation & Development II-16
Acquisition of Technology II-16
�Economics� of Chiral Technology II-17

5. Chiral Analysis Products II-18
Chiral Analytical Chromatography II-18
Chiral Liquid Chromatography II-18
Supercritical Fluid Chromatography - Substitute to LC for
Enantiomer Separations II-18
Chiral Gas Chromatography II-18
Chiral Simulated Moving Bed Chromatography II-19
Partition Chromatography II-19
Adsorption Chromatography II-19
Computer Assisted Resolution II-19
Chiral Polarimetry II-20
Other Chiral Analytical Techniques II-20
Calorimetry II-20
Differential Scanning Calorimetry (DSC) II-20
Enzymatic Assay II-20
Immunoassay II-21
Isotope Dilution II-21
Nuclear Magnetic Resonance (NMR) II-21
X-Ray Crystallography II-21

6. Application Markets II-22
Pharmaceuticals - The Largest Market II-22
Changing Face of the Pharmaceutical Industry II-22
Analysis of Chiral Drugs II-22
Select Companies Involved in Chiral Technology Market II-23
Table 2: Single-Enantiomer Drugs Market Worldwide (2006):
Sales of Select Leading Brands (In US$ Billion) (includes
corresponding Graph/Chart) II-23
Drugs Built on Chiral Technology II-24
Analgesics II-24
Anesthetics II-24
Anti-Infective Products II-24
Cardiovascular System (CVS) Products II-25
Angiotensin-Converting Enzyme (ACE) Inhibitors II-25
Beta-Blockers II-25
Calcium Channel Blockers II-25
Diuretics II-25
Vasodilators II-25
Central Nervous System (CNS) Agents II-25
Anticonvulsants II-25
Sedatives and Tranquilizers II-26
Stimulants and Antidepressants II-26
Oncogenic (Cancer-Treatment) Products II-26
Biochemicals II-26
Oligonucleotides II-26
Oxyacids II-27
Amino Acids II-27
Sugars and Other Oligosaccharides II-27
Vitamins II-28
Peptides II-28
Pesticides - A Thriving Market II-29
Herbicides II-29
Insecticides II-29
Fungicides II-30
Other Products II-30
Liquid Crystals II-30
Flavor and Aroma Chemicals II-31

7. Chiral Isomerism II-32
Organic Chemical Isomerism Types II-32
Structural Isomerism II-32
Chain Isomerism II-32
Position Isomerism II-32
Functional Group Isomerism II-32
Stereoisomerism II-32
Dynamic Isomerism (Tautomerism) II-33
Patents II-33

8. Regulatory & Environmental Issues II-34

9. Product Introductions II-35
Degussa Develops Novel Processes to Synthesize (S) CAP II-35
Regis Technologies, Inc. Launches RegisPack Chiral II-35
Columns II-35
Sigma-Aldrich Introduces ChiroSolv� Kits II-35
Sigma-Aldrich Launches Ascentis Express HPLC Columns II-35
Evolved Nanomaterial Releases Revolutionary Analytical Chiral
Column II-36
BASF Develops Novel Process to Produce Chiral Intermediates II-36
Chiral Quest Launches C3 TunePhos II-36

10. Recent Industry Activity II-37
Cambrex to Buy ProSyntest AS II-37
Johnson Matthey and X-Zyme Sign Licensing Agreement II-37
Chiral Quest Starts a New Production Facility II-37
Chiral Quest Completes Reverse Merger with Surg II II-37
DSM and IEP Extend Partnership II-37
Shasun Chemicals Acquires Rhodia Pharma Solutions II-38
Sigma-Aldrich Corp Acquires Astec II-38
Solvias Receives License for MeOBIPHEP Catalyst Technology II-38
Codexis Acquires Juelich Fine Chemicals II-38
ChiroBlock Exits from Chiral Compounds Business II-38
Chiral Quest Opens New Facility in China II-38
Chiral Quest to Supply C3 TunePhos to Phoenix Chemicals II-38
Lonza and Codexis Sign Agreement for Biocatalysis Process II-39
DSM Signs Licensing Agreement with Chiral Quest II-39
Chiral Quest Signs Distribution Agreement with Aldrich Chemical II-39
BASF and Solvias to Collaborate on Chiral Molecule Development II-39
Chiral Quest and Avantium Enter into Partnership II-39

11. Focus on Select Players II-40
Albemarle Corporation (USA) II-40
BASF AG (Germany) II-40
Cambrex Corp. (USA) II-40
Chiral Quest Inc (US) II-41
Dalco ChromTech AB (Sweden) II-41
Daicel Chemical Industries Ltd. (Japan) II-41
DSM Pharmaceutical Products (Netherlands) II-41
DowpharmaSM (USA) II-42
Johnson Matthey PLC (UK) II-42
Regis Technologies Inc (USA) II-42
Shasun Chemicals and Drugs Limited (India) II-43
Solvias (Switzerland) II-43
Sigma Aldrich Corp (USA) II-43
Suven Life Sciences Ltd. (USA) II-43

12. Global Market Perspective II-45
Table 3: World Recent Past, Current & Future Analysis for
Chiral Technology Enabling Products by Geographic Region -
US, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) II-45

Table 4: World Long-term Projections for Chiral Technology
Enabling Products by Geographic Region - US, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-46

Table 5: World 10-Year Perspective for Chiral Technology
Enabling Products by Geographic Region - Percentage Breakdown
of Value Sales for US, Japan, Europe, and Rest of World
Markets for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) II-47

Table 6: World Recent Past, Current & Future Analysis for
Chiral Intermediates by Geographic Region - US, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2010
(includes corresponding Graph/Chart) II-48

Table 7: World Long-term Projections for Chiral Intermediates
by Geographic Region - US, Japan, Europe, and Rest of World
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-49

Table 8: World 10-Year Perspective for Chiral Intermediates
by Geographic Region - Percentage Breakdown of Value Sales
for US, Japan, Europe, and Rest of World Markets for Years
2003, 2008 & 2012 (includes corresponding Graph/Chart) II-50

Table 9: World Recent Past, Current & Future Analysis for
Chiral Analytical Products by Geographic Region - US, Japan,
Europe, and Rest of World Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2000 through
2010 (includes corresponding Graph/Chart) II-51

Table 10: World Long-term Projections for Chiral Analytical
Products by Geographic Region - US, Japan, Europe, and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) II-52
TABLE 11: World 10-Year Perspective for Chiral Analytical
Products by Geographic Region - Percentage Breakdown of
Value Sales for US, Japan, Europe, and Rest of World Markets
for Years 2003, 2008 & 2012 (includes corresponding Graph
/Chart) II-53
Table 12: World Recent Past, Current & Future Analysis for
Other Chiral Technology Enabling Products by Geographic Region
- US, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) II-54

Table 13: World Long-term Projections for Other Chiral
Technology Enabling Products by Geographic Region - US,
Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) II-55

Table 14: World 10-Year Perspective for Other Chiral
Technology Enabling Products by Geographic Region - Percentage
Breakdown of Value Sales for US, Japan, Europe, and Rest of
World Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) II-56

Table 15: World Recent Past, Current & Future Analysis for
Chiral Technology in Pharmaceuticals by Geographic Region -
US, Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) II-57

Table 16: World Long-term Projections for Chiral Technology
in Pharmaceuticals by Geographic Region - US, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-58

Table 17: World 10-Year Perspective for Chiral Technology in
Pharmaceuticals by Geographic Region - Percentage Breakdown of
Value Sales for US, Japan, Europe, and Rest of World Markets
for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) II-59

Table 18: World Recent Past, Current & Future Analysis for
Chiral Technology in Agrochemicals by Geographic Region - US,
Japan, Europe, and Rest of World Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) II-60

Table 19: World Long-term Projections for Chiral Technology
in Agrochemicals by Geographic Region - US, Japan, Europe,
and Rest of World Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) II-61

Table 20: World 10-Year Perspective for Chiral Technology in
Agrochemicals by Geographic Region - Percentage Breakdown of
Value Sales for US, Japan, Europe, and Rest of World Markets
for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) II-62

III. MARKET

1. The United States III-1
A.Market Analysis III-1
Overview III-1
Product Introductions/Developments III-1
Strategic Corporate Developments III-2
Select Players III-3
Albemarle Corporation III-3
Cambrex Corp. III-3
Chiral Quest Inc III-4
DowpharmaSM III-4
Regis Technologies Inc III-4
Sigma Aldrich Corp III-5
Suven Life Sciences Ltd. III-5
B.Market Analytics III-6
Table 21: US Recent Past, Current & Future Analysis for Chiral
Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-6

Table 22: US Long-term Projections for Chiral Technology
Enabling Products by Product Segment - Intermediates,
Analytical, and Other Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) III-6

TABLE 23: US 10-Year Perspective for Chiral Technology
Enabling Products by Product Segment - Percentage Breakdown
of Value Sales for Intermediates, Analytical, and Other
Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) III-7

Table 24: US Recent Past, Current & Future Analysis for
Chiral Technology by End-Use Segment - Pharmaceuticals, and
Agrochemicals Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-8

Table 25: US Long-term Projections for Chiral Technology by
End-Use Segment - Pharmaceuticals, and Agrochemicals Markets
Independently Analyzed with Annual Sales Figures in US$
Million for Years 2011 through 2015 (includes corresponding
Graph/Chart) III-8

Table 26: US 10-Year Perspective for Chiral Technology by
End-Use Segment - Percentage Breakdown of Value Sales for
Pharmaceuticals, and Agrochemicals Markets for Years 2003,
2008 & 2012 III-9

2. Japan III-10
A.Market Analysis III-10
Outlook III-10
Daicel Chemical Industries Ltd - A Major Player III-10
B.Market Analytics III-11
Table 27: Japanese Recent Past, Current & Future Analysis for
Chiral Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-11

Table 28: Japanese Long-term Projections for Chiral Technology
Enabling Products by Product Segment - Intermediates,
Analytical, and Other Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) III-11

Table 29: Japanese 10-Year Perspective for Chiral Technology
Enabling Products by Product Segment - Percentage Breakdown of
Value Sales for Intermediates, Analytical, and Other Markets
for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-12

Table 30: Japanese Recent Past, Current & Future Analysis for
Chiral Technology by End-Use Segment - Pharmaceuticals, and
Agrochemicals Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-13

Table 31: Japanese Long-term Projections for Chiral Technology
by End-Use Segment - Pharmaceuticals, and Agrochemicals
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-13

Table 32: Japanese 10-Year Perspective for Chiral Technology
by End-Use Segment - Percentage Breakdown of Value Sales for
Pharmaceuticals and Agrochemicals Markets for Years 2003,
2008 & 2012 III-14

3. Europe III-15
A.Market Analysis III-15
Overview III-15
Product Introductions III-15
Strategic Corporate Developments III-16
Select Players III-17
BASF AG (Germany) III-17
Dalco ChromTech AB (Sweden) III-18
DSM Pharmaceutical Products (Netherlands) III-18
Johnson Matthey PLC (UK) III-18
Solvias (Switzerland) III-19
B.Market Analytics III-19
Table 33: European Recent Past, Current & Future Analysis for
Chiral Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-19

Table 34: European Long-term Projections for Chiral Technology
Enabling Products by Product Segment - Intermediates,
Analytical, and Other Markets Independently Analyzed with
Annual Sales Figures in US$ Million for Years 2011 through
2015 (includes corresponding Graph/Chart) III-20

Table 35: European 10-Year Perspective for Chiral Technology
Enabling Products by Product Segment - Percentage Breakdown of
Value Sales for Intermediates, Analytical, and Other Markets
for Years 2003, 2008 & 2012 (includes corresponding
Graph/Chart) III-20

Table 36: European Recent Past, Current & Future Analysis for
Chiral Technology by End-Use Segment - Pharmaceuticals, and
Agrochemicals Markets Independently Analyzed with Annual Sales
Figures in US$ Million for Years 2000 through 2010 (includes
corresponding Graph/Chart) III-21

Table 37: European Long-term Projections for Chiral Technology
by End-Use Segment - Pharmaceuticals, and Agrochemicals
Markets Independently Analyzed with Annual Sales Figures in
US$ Million for Years 2011 through 2015 (includes
corresponding Graph/Chart) III-21

Table 38: European 10-Year Perspective for Chiral Technology
by End-Use Segment - Percentage Breakdown of Value Sales for
Pharmaceuticals, and Agrochemicals Markets for Years 2003,
2008 & 2012 III-22

4. Rest of World III-23
A.Market Analysis III-23
Outlook III-23
India III-23
Chiral Drugs in Indian Market III-23
China-A Hub for Pharmaceutical Manufacturing III-23
Strategic Corporate Development III-23
Shasun Chemicals and Drugs Limited - A Major Indian Player III-23
B.Market Analytics III-24
Table 39: Rest of World Recent Past, Current & Future Analysis
for Chiral Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2000 through 2010 (includes corresponding Graph/Chart) III-24

Table 40: Rest of World Long-term Projections for Chiral
Technology Enabling Products by Product Segment -
Intermediates, Analytical, and Other Markets Independently
Analyzed with Annual Sales Figures in US$ Million for Years
2011 through 2015 (includes corresponding Graph/Chart) III-25

Table 41: Rest of World 10-Year Perspective for Chiral
Technology Enabling Products by Product Segment - Percentage
Breakdown of Value Sales for Intermediates, Analytical, and
Other Markets for Years 2003, 2008 & 2012 (includes
corresponding Graph/Chart) III-25

Table 42: Rest of World Recent Past, Current & Future Analysis
for Chiral Technology by End-Use Segment - Pharmaceuticals,
and Agrochemicals Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2000 through 2010
(includes corresponding Graph/Chart) III-26

Table 43: Rest of World Long-term Projections for Chiral
Technology by End-Use Segment - Pharmaceuticals, and
Agrochemicals Markets Independently Analyzed with Annual
Sales Figures in US$ Million for Years 2011 through 2015
(includes corresponding Graph/Chart) III-26

Table 44: Rest of World 10-Year Perspective for Chiral
Technology by End-Use Segment - Percentage Breakdown of Value
Sales for Pharmaceuticals, and Agrochemicals Markets for Years
2003, 2008 & 2012 III-27

IV. COMPETITIVE LANDSCAPE